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Description
CD138 Recombinant Rabbit mAb (SDT-R120)Product Specification Host Rabbit Antigen CD138 Synonyms Syndecan 1, SYND1, SDC1 Immunogen N A Location Membrane Accession P18827 Clone Number SDT R120 Antibody Type Rabbit mAb Application IHC P, ICC Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution
Product Specification
| Host | Rabbit |
| Antigen | CD138 |
| Synonyms | Syndecan-1, SYND1, SDC1 |
| Immunogen | N/A |
| Location | Membrane |
| Accession | P18827 |
| Clone Number | SDT-R120 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, ICC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| ICC | 1:25 |
Background
Syndecan-1 (CD138) is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides, including extracellular matrix components and potent mediators of proliferation, adhesion and migration. For this reason, it has been studied extensively with respect to carcinomas and tumor progression. Frequently, but not always, syndecan-1 levels decrease as tumor grade, stage and invasiveness and dedifferentiation increase. However, in some tumors, levels of syndecan-1 increase, but the characterization of its distribution is relevant. There can be loss of membrane staining, but acquisition of cytoplasmic and/or nuclear staining that is abnormal. Moreover, the appearance of syndecan-1 in the tumor stroma, either associated with its cellular component or the collagenous matrix, is nearly always a sign of poor prognosis [PMID: 33921767].
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