SKU: 21836505566

Pericentrin Recombinant Rabbit mAb (S-3493)

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Description

Pericentrin Recombinant Rabbit mAb (S-3493)Product Specification Host Rabbit Antigen Pericentrin Synonyms Kendrin; Pericentrin B; KIAA0402; PCNT2; PCNT Location Cytoplasm, Cytoskeleton Accession O95613 Clone Number S 3493 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%

Product Specification


Host Rabbit
Antigen Pericentrin
Synonyms Kendrin; Pericentrin-B; KIAA0402; PCNT2; PCNT
Location Cytoplasm, Cytoskeleton
Accession O95613
Clone Number S-3493
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:2000 Hu, Ms, Rt
ICC 1:500 Hu, Ms

Background

Pericentrin (PCNT, also called kendrin or pericentrin-B) is a large, highly conserved coiled-coil scaffold protein encoded by the PCNT gene on chromosome 21, which localizes to the centrosome and pericentriolar material (PCM) via its C-terminal PACT domain, anchoring γ-tubulin complexes and other regulatory proteins to organize microtubule nucleation and anchoring, thereby orchestrating centrosome assembly, mitotic spindle formation, cell-cycle progression and primary cilium biogenesis; mutations or dysregulation of PCNT underlie disorders such as microcephalic osteodysplastic primordial dwarfism type II, Seckel syndrome, ciliopathies, and have been linked to cancer, mental disorders and altered insulin secretion in β-cells.

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SKU: 21836505566

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