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Description
CD22 Recombinant Rabbit mAb (SDT-R113)Product Specification Host Rabbit Antigen CD22 Synonyms BL CAM, Siglec 2, T cell surface antigen Leu 14 Immunogen N A Location Cell membrane Accession P20273 Clone Number SDT R113 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | CD22 |
| Synonyms | BL-CAM, Siglec-2, T-cell surface antigen Leu-14 |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | P20273 |
| Clone Number | SDT-R113 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | null |
| WB | 1:1000 | null |
| ICC | 1:500 | null |
| IP | 1:50 | null |
Background
CD22 and CD19 represent two specialized costimulatory or coreceptor cell surface molecules [PMID: 9476671, PMID: 9175829, PMID: 15364057, PMID: 9203413, PMID: 9047233] that also function as “response regulators” to modulate the intensity, quality, and duration of homeostatic and BCR‐induced signals [PMID: 9695183, PMID: 9695185]. Response regulators carry out broader functions than costimulatory molecules because they establish intrinsic signaling thresholds that provide a context for other transmembrane and cytoplasmic signals. CD22 is also a lectin‐like member of the Ig superfamily expressed exclusively by all mature B‐lineage cells, which binds ligands in vivo to regulate BCR and CD19 signal transduction, and provide essential survival signals.
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Exchange/Return Notes
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