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Description
PCSK9 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PCSK9, FH3, PC9, FHCL3 Accession Q80W65 Amino Acid Sequence Gln35 Gln694, with C terminal 10* His Tag
Product Specification
| Species | Mouse |
| Synonyms | PCSK9, FH3, PC9, FHCL3 |
| Accession | Q80W65 |
| Amino Acid Sequence | Gln35-Gln694, with C-terminal 10* His Tag QDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 60-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Jaén R I. et al. (2022) Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release. Int J Mol Sci. 23(16): 9114. |
Background
PCSK9 (proprotein convertase subtilisin-kexin type 9) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. PCSK9 undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism.
Atherosclerosis is a cardiovascular disease caused mainly by dyslipidemia and is characterized by the formation of an atheroma plaque and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that induces the degradation of the LDL receptor (LDLR), which contributes to increased levels of LDL cholesterol and the progress of atherosclerosis.
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4.6 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Good purchase!!
Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1)
It’s so comfortable!! Perfect cooling, soft to the touch, perfect length (I’m 5’4) it’s fluffy and firm. There is a little weight to it but still very nice!!
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Reviewed in the United States on April 30, 2026
★★★★★ 5
Great for hot 🥵 sleepers!!
Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1)
I absolutely love this body pillow!!! It is a nice looking pillow, silky on the cooling side and comfy on the bamboo side. The size is perfect and it really is cooling for someone like me that is menopausal and sleeps very hot 🥵🥵🥵 It keeps me comfortable all night.. I like the amount of fill inside the pillow. As a side sleeper with back pain the thickness of the memory foam keeps my spine aligned perfectly and doesn't flatten out. Best purchase I've made for cooling comfort at a decent price point!!
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Reviewed in the United States on March 2, 2026
★★★★★ 5
Nice and adjustable by removing stuffing
Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1), Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1)
I really like this pillow.
It fluffs up huge, and you can throw it in the dryer to fluff it up faster.
It’s soft, cozy, and cooling with the cool side of the cover.
What I really love about it though is you can remove stuffing easily to adjust the size and weight. It’s pretty big and heavy.
It was a bit too puffy and heavy for my taste so I removed a garbage bags worth of stuffing and now it’s perfect!!
Great body pillow I totally recommend.
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Reviewed in the United States on November 21, 2025
★★★★★ 4
Nice Firm
Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1)
So I don’t love this body pillow but I do like it. This is a great pillow for anything the only downside is that it’s super heavy. It’s not something you would throw around the house that’s for sure but it does do its job when I’m sleeping and need something in between my legs my knees. It’s nice and firm not floppy, it’s perfect for a body. It’s perfect height, I’m 5’4 so it is perfect length wise. If you’re looking for something fluffy and lightweight I wouldn’t suggest this pillow but if you’re looking for something you can use for say menstrual cramps or a bad back and simply just to have between your legs than this is the pillow you want. I recommend it to anyone who doesn’t mind a little weight while making your bed. I give it 8:10.
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Reviewed in the United States on August 13, 2025
★★★★★ 5
Love this pillow!
Color: Blue(one-sided Cooling), Size: 20"x54"(Pack of 1)
Love this pillow. I bought 2. No weird smell and the cover is half cooling and half bamboo. It is also removable so that it can be washed. The inner pillow insert has a thin permanent cover on it to keep the shredded memory foam enclosed, this is standard compared to other memory foam pillows I've bought in the past. I got them on a used like new discount, and they were still vaccum sealed and truly like new. I couldn't be happier with these pillows, I am so glad I got 2.
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Reviewed in the United States on May 20, 2026