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Description
TrkC Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TrkC, Ntrk3 Accession Q96CY4 Amino Acid Sequence Cys32 Asp428, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TrkC, Ntrk3 |
| Accession | Q96CY4 |
| Amino Acid Sequence | Cys32-Asp428, with C-terminal Human IgG1 Fc CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Khotskaya Y B. et al. (2017). Targeting TRK family proteins in cancer. Review. 173:58-66. |
Background
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of neurotrophins to TRK proteins induces receptor dimerization, phosphorylation, and activation of the downstream signaling cascades via PI3K, RAS/MAPK/ERK, and PLC-gamma. TrkC functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. TrkC is a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
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Exchange/Return Notes
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4.7 ★★★★★
Based on 25 reviews
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Product Reviews
★★★★★ 4
Soft non-squeaker
Color: Enno
Our son's dog loved this non-squeaker! Very easy to carry around the house and cuddle with on his bed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 22, 2025
★★★★★ 5
Molly loves this
Color: Elroy
My small dog loves this
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 4, 2026
★★★★★ 1
Very disappointed
Color: Enno
The toy was split into pieces in the first 5 minutes of the dog playing with it.
Apparently not as durable as advertised.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 16, 2026
★★★★★ 3
Dog toys need to be sturdy - maybe you should sew them with a 5-thread machine like a serger?
Color: Elroy
My dog's full size teddy is disintegrating, so I ordered this one. It's very cute, but the seams are really weak. I've already repaired 3 seams in just a few weeks.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 13, 2026
★★★★★ 5
Great toy!
Color: Elly
Great toy! Dog loves it and it is durable. We’ve bought other toys that he tore apart within a week, not this one! He takes it everywhere we go!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
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