E-Selectin/CD62E His Tag Protein, Cynomolgus
SKU: 73272109353

E-Selectin/CD62E His Tag Protein, Cynomolgus

Sale price$108.00 Regular price$120.00
Save 10%

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 7 - Jul 12

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus

Product Specification


Species Cynomolgus
Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2
Accession XP_005539998.2
Concentration >95% by SDS-PAGE & SEC-HPLC
Amino Acid Sequence

Trp22-Pro556 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

90-110kDa (Reducing)

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34.

Background

E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 73272109353

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.0 ★★★★★
Based on 1899 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
B
Verified Purchase
Beth in Texas
Grantham, US
★★★★★ 5
Great blouse for work!
I purchased this red blouse as a Prime deal for Valentine’s Day. I wore to work with black pants. I think this is a great work blouse and intend to buy it in more colors. It is cute, not very formfitting, but still has a V-neck. I would say it runs slightly large. It is also long in length. For reference, I am usually a large or XL because I am busty, but the large was plenty big and I was wondering if I could fit into a medium... If you want a more flowing top, this is definitely a great choice. I think this would look great with white jeans also and perhaps even tied at the waist. As some reviewers have said, it does wrinkle easily. wWhen I got it from Amazon, I ironed it inside out, and all of the wrinkles came out. Perhaps, if you were sitting all day, it would be very wrinkly in the front. I sit for my job, but I did not tuck in the blouse - I kind of had it flow away from my body and it stayed mostly wrinkle free all day. I plan to buty in more colors!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 12, 2023
D
Verified Purchase
diane trowbridge
Lexington, US
★★★★★ 3
Lovely top
Size: Large, Color: Mini Leopard
Beautiful top and size was true to what was listed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 12, 2026
P
Verified Purchase
Poopylou
Battle Creek, US
★★★★★ 5
Very nice
Size: Large, Color: Blue White Petal
Perfect length and fit and doesn't cling if you like a more relaxed look. I purchased 3 of these for work and I love them. I can wear them with khaki cropped pants and sandals, very cute. After washing and line drying there hasn't been any shrinkage and the fabric stays nice. Perfect for warmer weather climates!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 18, 2026
R
Verified Purchase
R daugh
Battle Creek, US
★★★★★ 5
Relaxed fit, business or casual summer blouse.
Size: X-Large, Color: Mini Leopard
Light weight summer material, soft, nice feel. Fits well. Color as advertised. I recommend highly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 24, 2026
M
Verified Purchase
Maris Goldberg
West Palm Beach, US
★★★★★ 4
Sizing seems to be different depending on color!
Size: Large, Color: Mini Leopard
Ordered in Mini Leopard in Large and Pink in Medium. The Mini leopard was too big and the Pink was to small! Decided to return both and order the pink in large. That fits!!! Sizing is different in different colors! Like the style and hopefully it will wash okay. Kept the pink, large! It did come extremely creased!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 27, 2026

recommand products