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when was semaglutide first used

when was semaglutide first used History of GLP-1 Medications

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J. Marchessault
Fort Morgan, US
★★★★★ 5
Miracle cream!
This cream is unbelievable. goes in instantly, makes hands soft after one application and creates a barrier to protect your hands against cold and water. I live in VT and have tried numerous "extreme" hand creams that are heavy and greasy and useless~ this one is the best. I also like that it is fragrance-free except for that mild "Avene" spring water smell. I have two tubes, one for my night table and one next to the kitchen sink. I am 47 and have tried numerous face and body products`` you could say I used to be a "junkie" :) but I always come back to Avene. I have extremely sensitive skin and Avene products are a life saver.
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Reviewed in the United States on January 30, 2015
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Samantha Downing
San Leandro, US
★★★★★ 4
Hydrating
Light weight
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Reviewed in the United States on March 16, 2026
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Jean
Cuba, US
★★★★★ 5
My 75 year old hands appear softer and younger!
Avene Cicalfate Restorative Hand cream leaves my hands feeling very soft! A little goes a long way, I have had mine for a year. Soon I will be purchasing another tube. Yes, it is a little pricey for a hand cream, but does the job better then any other product I have used on my hands. Highly recommend this hand cream if you have dry, sensitive skin. It also has no added fragrance which I really appreciate!
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Reviewed in the United States on June 4, 2025
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Olga
Port Orchard, US
★★★★★ 5
Excellent product at a very good price. I will buy it again.
This is an excellent product at a fair price. The cream creates a barrier that protects the skin, while mosturizes it. leaves hands very soft, and it doesn't feel greasy. I know that this is a favorite brand (Avene) in France, and Amazon offers it at a very good price. I will buy it again, from Amazon. I bought it this year in Paris, and it was more expensive there.
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Reviewed in the United States on May 27, 2015
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armine arakelian
Belleville, US
★★★★★ 1
Drying formula and smell bad
Smell so bad and made my hands dry instead of moisturizing. The formula is watery. Maybe it’s fake or expired I am not sure.
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Reviewed in the United States on December 25, 2025

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