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Description
SR-B2/LIMPII Fc Chimera Protein, HumanProduct Specification Species Human Synonyms SR B2, SCARB2, CD36L2, LIMP2, LIMPII Accession Q14108 Amino Acid Sequence Arg27 Thr432, with C terminal human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | SR-B2, SCARB2, CD36L2, LIMP2, LIMPII |
| Accession | Q14108 |
| Amino Acid Sequence | Arg27-Thr432, with C-terminal human IgG1 Fc RVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 87-107kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Neculai D. et al. (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504: 172-176. |
Background
LIMPII (Lysosomal Integral Membrane Protein II), also known as LPG85 (85 kDa lysosomal membrane sialoglycoprotein) and as CD36 antigen-like 2 (CD36L2), is a major lysosomal membrane protein. LIMP-II is a type-III protein that traverses the membrane twice, with an N-terminal transmembrane anchor as a result of an uncleaved signal peptide and a second membrane spanning region near the C-terminus, followed by a 20 amino acid cytoplasmic tail. LIMPII is currently known to be a member of a superfamily of scavenger receptor proteins (class B), which also includes scavenger receptor (SR)-B1 and SR-B3. These three proteins share their structure, which comprises two transmembrane domains, a relatively large extracellular domain, and both the amino and carboxyl termini located within the cytoplasm. LIMPII as the mannose-6-phosphate- independent trafficking receptor for beta-glucocerebrosidase.
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4.2 ★★★★★
Based on 13 reviews
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Product Reviews
★★★★★ 5
Worth the money
The ring is beautiful, very classy
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Reviewed in the United States on March 20, 2024
★★★★★ 5
Stunning
Gem Type: Topaz, Ring Size: 8
It’s really simple & elegant. I receive compliments every time I wear it.
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Reviewed in the United States on September 19, 2021
★★★★★ 5
Beautiful stone
I'm in awe at how beautiful this ring is. The band is alittle thin bit it just makes that stone stand out more!!
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Reviewed in the United States on April 17, 2024
★★★★★ 5
Excellent
Gem Type: No Gemstone, Ring Size: 9
I don't usually leave reviews but this ring is gorgeous. It's weight is good. Design is beautiful. Some gold u buy can be really thin n flimsy but this ring is substantial enough. Im truly enjoying it. Will buy from them again.
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Reviewed in the United States on April 6, 2026
★★★★★ 5
Replaced wedding band after 43 years
Gem Type: No Gemstone, Ring Size: 10
I am thrilled with this ring. After 43 years, due to arthritis and aging my knuckles were too swollen for my original band. This is a very pretty, sturdy, detailed ring. I have received many compliments and I am well pleased with the quality. It was also on time, well packaged and a notice was sent of it's arrival. Very nice. Highly recommend.
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Reviewed in the United States on August 11, 2023