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Description
Cytokeratin 19 fragment (CY211) Recombinant Rabbit mAb (SDT-197-28)Product Specification Host Rabbit Antigen Cytokeratin 19 fragment (CY211) Synonyms CYFRA 21 1 Immunogen Recombinant Protein Location Cytoplasm Accession P08727 Clone Number SDT 197 28 Antibody Type Rabbit mAb Application WB, IHC P, ICC Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Cytokeratin 19 fragment (CY211) |
| Synonyms | CYFRA 21-1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | P08727 |
| Clone Number | SDT-197-28 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | null |
| IHC-P | 1:1000 | null |
| ICC | 1:250 | null |
Background
Cytokeratin 19 fragment (CYFRA 21-1) is a fragment of cytokeratin 19 that is typically associated with epithelial cell cancers, including NSCLC, and is typically associated with the SQLC type. Since cytokeratins are structural proteins of keratin-containing intermediate filaments found in the epithelial cells, their degradation produces soluble fragments which are measurable in the blood of lung cancer patients as a tumor marker. Other examples of cytokeratin fragments include tissue polypeptide antigen and tissue polypeptide-specific antigen. CYFRA 21-1 is known to be correlated with disease response and the prognosis of lung cancer but cannot be used to differentiate cancer patients from patients with respiratory diseases.
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