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Description
Alexa Fluor® 488 Rat Anti-Mouse CD138 Antibody (S-R514)Product Specification Host Rat Antigen CD138 Synonyms Syndecan 1; SYND1; Synd 1; Sdc1 Location Secreted, Membrane Accession P18828 Clone Number S R514 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Rat |
| Antigen | CD138 |
| Synonyms | Syndecan-1; SYND1; Synd-1; Sdc1 |
| Location | Secreted, Membrane |
| Accession | P18828 |
| Clone Number | S-R514 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD138 (syndecan-1) is a type-I transmembrane heparan-sulfate/chondroitin-sulfate proteoglycan that tethers the cytoskeleton to the extracellular matrix, mediating adhesion, migration, and exosome biogenesis while acting as a co-receptor for growth factors and chemokines. It is constitutively expressed on epithelial cells and terminally differentiated plasma cells (making it a selective marker for plasma-cell neoplasms), but absent from mature B cells. Shed soluble CD138 is a prognostic indicator in multiple myeloma and other cancers; its overexpression or loss correlates with tumor progression, angiogenesis, and metastasis in solid tumors such as breast, colorectal, and liver cancers.
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