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Description
p40 Recombinant Rabbit mAb (SDT-166-36)Product Specification Host Rabbit Antigen p40 Synonyms BC28 Immunogen Synthetic Peptide Location Nucleus Accession Q9H3D4 4 Clone Number SDT 166 36 Antibody Type Recombinant mAb Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C
Product Specification
| Host | Rabbit |
| Antigen | p40 |
| Synonyms | BC28 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q9H3D4-4 |
| Clone Number | SDT-166-36 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| IHC-P | 1:500 | null |
Background
p63 (TAp63) is closely related to p40 (ΔNp63) as both proteins represent isoforms of the p63 gene with distinct molecular functions. While “full length” p63 (TAp63) activates p53 target genes such as p21 or BAX, the shorter transcript p40 (ΔNp63) inhibits activation of p53 and “full length” p63. Among carcinomas, p40 has approximately the same sensitivity as p63 but a higher specificity, as the TAp63 isoform is expressed more widespread in eg., adenocarcinomas. Moreover, p63 occur in lymphomas that are p40 negative.
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